A Modernist painter considered too sentimental by Ashcan school founder Robert Henri, Myers' canvases would none the less depict urban scenes in an unromantic light, and remarkably untraditional methods. He would work in many mediums, including crayon and pencil, pastel, watercolor and printmaking, and his subjects would be quite diverse, but usually leant towards the urban and cityscapes as well as the street scenes and its people.
He was born in Virginia in 1867 and began his art studies at the Cooper Union School in 1887. From the beginning of his career he turned to the streets around him for his subject matter, and never adhered to the academic training he received under George de Forest Brush.
He decided that he should complete his education with a journey to Paris, but soon returned after deciding that his experience in the city would not be of much benefit to his art. During this same period in his life he made the acquaintance of art dealer William Macbeth, and with his support Myers was able to become a well-known artist.
He exhibited widely, winning a medal at the St. Louis World's Fair in 1904 and staging a solo exhibition before the Ashcan school debuted in its own famous show. Myers never exhibited with the group, but he would go on to exhibit with the Independent Artists in 1910 and serve as one of the main organizers of the famous Armory Show of 1913, which introduced modern art to the American public.
He worked and exhibited throughout his life, winning many major awards, including five from the prestigious National Academy of Design alone. His works are in many important collections including such major museums as the Corcoran Gallery in Washington, D.C. and the Metropolitan Museum of Art in New York.